Gardaí in Granard have confirmed that an accident involving five vehicles on the Cavan Road outside the town took place this afternoon.
One person has been airlifted to hospital while a number of others have sustained non-life threatening injuries.
The N55 is currently closed at the Cavan/Longford county bounds, just north of Granard, as emergency services deal with the collision.
Motorists are being advised to use alternative routes.
The road will remain closed as a forensic examination gets underway.
A garda investigation has also been launched.